Colloidal self-assembly of soft neural interfaces from injectable photovoltaic microdevices

Abstract

Biomimetic retinas with a wide field of view and high resolution are in demand for neuroprosthetics and robot vision. Conventional neural prostheses are manufactured outside the application area and implanted as a complete device using invasive surgery. Here, a minimally invasive strategy based on in situ self-assembly of photovoltaic microdevices (PVMs) is presented. The photoelectricity transduced by PVMs upon visible light illumination reaches the intensity levels that could effectively activate the retinal ganglion cell layers. The geometry and multilayered architecture of the PVMs along with the tunability of their physical properties such as size and stiffness allow several routes for initiating a self-assembly process. The spatial distribution and packing density of the PVMs within the assembled device are modulated through concentration, liquid discharge speed, and coordinated self-assembly steps. Subsequent injection of a photocurable and transparent polymer facilitates tissue integration and reinforces the cohesion of the device. Taken together, the presented methodology introduces three unique features: minimally invasive implantation, personalized visual field and acuity, and a device geometry adaptable to retina topography.