Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Milad Iranshahy; Mohammad Yahya Hanafi-Bojd; Seyed Hadi Aghili; Mehrdad Iranshahi; Seyed Mohammad Nabavi; Satar Saberi; Rosanna Filosa; Iman Farzam Nezhad; Maede Hasanpour

doi:10.1039/D3RA02772D

Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Milad Iranshahy,^a Mohammad Yahya Hanafi-Bojd,^b Seyed Hadi Aghili,^c Mehrdad Iranshahi,^d Seyed Mohammad Nabavi,

^ef Satar Saberi,^g Rosanna Filosa,^h Iman Farzam Nezhadⁱ and Maede Hasanpour

*^d

Author affiliations

* Corresponding authors

^a Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

^b Nanomedicine Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

^c Valiasr Hospital, Department of Neurosurgery, Tehran, Iran

^d Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
E-mail: Hasanpourmm3@mums.ac.ir, maede.hasanpour@yahoo.com

^e Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, San Salvatore Telesino, BN, Italy

^f Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Brazil

^g Department of Chemistry, Faculty of Science, Farhangian University, Tehran, Iran

^h Dipartimento di Scienze e Tecnologie, Università Degli Studi Del Sannio, Benevento, Italy

ⁱ Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract

Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, and permeability. Co-delivery with other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable drug leakage and increase selectivity towards target tissues. This review summarizes the methods of Cur-loaded MSN synthesis and functionalization and their application in various diseases, and also highlights the potential of Cur-loaded MSNs as a promising drug delivery system.

This article is part of the themed collection: 2023 Reviews in RSC Advances

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Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

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Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

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