Issue 19, 2023

Deoxyglucose-conjugated persistent luminescent nanoparticles for theragnostic application in fibrosarcoma tumor model

Abstract

Deoxyglucose conjugated nanoparticles with persistent luminescence have shown theragnostic potential. In this study, deoxyglucose-conjugated nano-particles with persistent luminescence properties were synthesized, and their theragnostic potential was evaluated in fibrosarcoma cancer cells and a tumor model. The uptake of nano-formulation was found to be higher in mouse fibrosarcoma (WEHI-164) cells cultured in a medium without glucose. Nanoparticles showed a higher killing ability for cancer cells compared to normal cells. A significant accumulation of nanoparticles to the tumor site in mice was evident by the increased tumor/normal leg ratio, resulting in a significant decrease in tumor volume and weight. Histopathological studies showed a significant decrease in the number of dividing mitotic cells but a greater number of apoptotic/necrotic cells in nanoparticle-treated tumor tissues, which was correlated with a lower magnitude of Ki-67 expression (a proliferation marker). Consequently, our results showed the potential of our nano-formulation for cancer theragnosis.

Graphical abstract: Deoxyglucose-conjugated persistent luminescent nanoparticles for theragnostic application in fibrosarcoma tumor model

Supplementary files

Article information

Article type
Paper
Submitted
21 Feb 2023
Accepted
10 Apr 2023
First published
28 Apr 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 13240-13251

Deoxyglucose-conjugated persistent luminescent nanoparticles for theragnostic application in fibrosarcoma tumor model

K. S. Sharma, P. K. Melwani, H. D. Yadav, R. Joshi, N. G. Shetake, A. K. Dubey, B. P. Singh, S. Phapale, P. P. Phadnis, R. K. Vatsa, R. S. Ningthoujam and B. N. Pandey, RSC Adv., 2023, 13, 13240 DOI: 10.1039/D3RA01169K

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