Issue 2, 2023, Issue in Progress

New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

Abstract

Distinct types of new boron fused primary amino amide organocatalysts were designed and synthesized from commercially available amino acids. Their catalytic activities were investigated in asymmetric crossed aldol reaction of ketones with aromatic aldehydes to afford the corresponding chiral anti-aldol adducts with good chemical yields, moderate diastereoselectivity and good to excellent enantioselectivities (up to 94% yields, up to 90 : 10 dr, up to 94% ee).

Graphical abstract: New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

Supplementary files

Article information

Article type
Paper
Submitted
05 Oct 2022
Accepted
20 Dec 2022
First published
04 Jan 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 888-894

New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds

Z. Begum, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M. Takeshita and H. Nakano, RSC Adv., 2023, 13, 888 DOI: 10.1039/D2RA06272K

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