Photoinduced C–H heteroarylation of enamines via quadruple cleavage of CF2Br2

Abstract

The C–H functionalization of enamines has attracted much attention over the past few years; however, the heteroarylation of enamines still remains rare. Herein, we wish to report a photoinduced three-component coupling/cyclization reaction for the de novo synthesis of 1,3,4-oxdiazole- or benzothiazole-functionalized enamines via quadruple cleavage of CF₂Br₂. Notably, the reaction provides an efficient and general approach for the C–H heteroarylation of enamines and exploits a new reactivity of CF₂Br₂, as the C1 source.