Issue 19, 2023
From the journal:

Organic Chemistry Frontiers

Enantioselective construction of spirodihydrofuran oxindoles via one-pot organo-/iodine sequential catalysis†

Ai-Bao Xia, ORCID logo *a   Li-Sha Huang,a   Chang-Ping Li, ORCID logo b   Qing-Bo Hu,a   Jin-Yao Zhu,a   Liang Baia  and  Dan-Qian Xu ORCID logo *a  

* Corresponding authors

a Catalytic Hydrogenation Research Centre, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou, China
E-mail: xiaaibao@zjut.edu.cn, chrc@zjut.edu.cn

b Hangzhou Environmental Protection Co., Ltd, Hangzhou 310063, P.R. China

Abstract

A highly efficient strategy was first developed for the enantioselective construction of spirodihydrofuran oxindoles via a one-pot Michael/iodization/SN2 nucleophilic substitution sequence. The reaction features easy operation and a transition-metal free process, and delivers spirodihydrofuran oxindoles with two adjacent tetrasubstituted carbon stereocenters.

Graphical abstract: Enantioselective construction of spirodihydrofuran oxindoles via one-pot organo-/iodine sequential catalysis

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Article information

DOI
https://doi.org/10.1039/D3QO01091K
Article type
Research Article
Submitted
14 Jul 2023
Accepted
18 Aug 2023
First published
19 Aug 2023

Org. Chem. Front., 2023,10, 4848-4853

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Enantioselective construction of spirodihydrofuran oxindoles via one-pot organo-/iodine sequential catalysis

A. Xia, L. Huang, C. Li, Q. Hu, J. Zhu, L. Bai and D. Xu, Org. Chem. Front., 2023, 10, 4848 DOI: 10.1039/D3QO01091K

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