Diverse synthesis of functionalized hydroquinoline derivatives from α-aryl vinylsulfonium salts

Abstract

Vinylsulfonium salt chemistry is becoming increasingly attractive in the synthesis of heterocyclic motifs for its high efficiency and versatility. In this article, we achieved diverse transformations of α-aryl vinylsulfonium salts under mild reaction conditions, affording various 1,2-dihydroquinoline and ring-fused tetrahydroquinoline skeletons in moderate to excellent isolated yields. The potential application of the method was demonstrated by a scale-up experiment and further derivatizations of the products. The developed protocol features mild and transition-metal-free reaction conditions, and easy operation.