A Sc(OTf)3-catalyzed one-pot two-step approach for spiro-oxindole dihydropyridine derivatives initiated by N-olefination of MBH carbonates

Abstract

A series of polyfunctionalized spiro-oxindole dihydropyridine frameworks have been synthesized via an efficient Sc³⁺-catalyzed one-pot stepwise reaction. This stepwise strategy involved the cleavage and formation of multiple C–X/C–C bonds, enabled by the N-olefination, Meinwald rearrangement and inverse-electron-demand aza-Diels–Alder reaction. This transformation exhibited many advantages, including readily available starting materials, mild reaction conditions, and high chemoselectivities and yields.