The application of NH4SCN as a nontoxic cyanide source for the divergent Strecker synthesis of aminonitriles and iminonitriles

Xiaofan Wang; Bingyue Zhao; Lingzhi Xu; Xuemin Li; Haofeng Shi; Yunfei Du

doi:10.1039/D2QO01692C

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The application of NH₄SCN as a nontoxic cyanide source for the divergent Strecker synthesis of aminonitriles and iminonitriles†

Xiaofan Wang,^a Bingyue Zhao,^a Lingzhi Xu,^a Xuemin Li,^a Haofeng Shi^a and Yunfei Du

*^a

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* Corresponding authors

^a School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
E-mail: duyunfeier@tju.edu.cn

Abstract

The reaction of arylaldehydes and arylamines with NH₄SCN in the presence of TBHP led to a divergent Strecker synthesis of aminonitriles and iminonitriles. The striking feature of this modified Strecker reaction is the application of nontoxic NH₄SCN as the cyanide source.

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Article information

DOI: https://doi.org/10.1039/D2QO01692C
Article type: Research Article
Submitted: 24 Oct 2022
Accepted: 04 Jan 2023
First published: 05 Jan 2023

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Org. Chem. Front., 2023,10, 1009-1014

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The application of NH₄SCN as a nontoxic cyanide source for the divergent Strecker synthesis of aminonitriles and iminonitriles

X. Wang, B. Zhao, L. Xu, X. Li, H. Shi and Y. Du, Org. Chem. Front., 2023, 10, 1009 DOI: 10.1039/D2QO01692C

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