Issue 13, 2023

Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

Abstract

The therapeutic efficacy of reactive oxygen species (ROS)-mediated cancer treatments is significantly limited by a shortage of substrates, such as hypoxia in photodynamic therapy (PDT). The development of an effective nanoplatform based on PDT toward hypoxic tumors remains a research imperative. Here, we report a triple ROS-generator, hyaluronic acid-modified Pt nanoparticles/carbon dots-loaded mesoporous silica (HA-PCD), which consists of Pt nanoparticles (NPs) and carbon dots (CDs)-loaded dendritic mesoporous silica nanoparticles (DMSNs) with further surface modifying hyaluronic acid (HA) for photodynamic/catalytic combination therapy of hypoxic tumors. Under 635 nm laser irradiation, HA-PCD generates singlet oxygen (1O2) due to the involvement of CDs photosensitizers. The loaded Pt NPs can not only enhance photodynamic therapy under hypoxic conditions by producing oxygen via catalase-mimicking activity, but also generate hydroxyl radicals (˙OH) and superoxide anions (O2˙−) for catalytic therapy because of its peroxidase- and oxidase-mimicking activities. Additionally, due to the interaction between HA and overexpressed receptors (cluster determinant 44) in cancer cells, HA-PCD exhibits tumor cell targetability. In this work, a novel nanoplatform for multiple ROS-mediated synergistic photodynamic/catalytic therapy of hypoxic tumors has been fabricated.

Graphical abstract: Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

Supplementary files

Article information

Article type
Research Article
Submitted
03 Jan 2023
Accepted
28 Mar 2023
First published
03 Apr 2023

Mater. Chem. Front., 2023,7, 2706-2720

Carbon dots/platinum nanoparticles-loaded mesoporous silica for synergistic photodynamic/catalytic therapy of hypoxic tumors

K. Liang, F. Zhao, F. Nan, J. Wang, Y. Zhang, J. Li, X. Xue, T. Chen, L. Kong, J. Ge and P. Wang, Mater. Chem. Front., 2023, 7, 2706 DOI: 10.1039/D3QM00008G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements