Issue 15, 2023

Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

Abstract

Nanozymes with intrinsic enzyme-like properties and excellent stability are promising alternatives to natural enzymes. Yet, their low density of active sites and unclear crystal structure have been the major obstacles that impede their progress. Single-atom nanozymes (SAzymes) have emerged as a unique system to mitigate these issues, due to maximal atomic utilization, well-defined electronic and geometric structures, and outstanding catalytic activity distinct from their nanosized counterparts. Furthermore, the homogeneously dispersed active sites and well-defined coordination structures provide rare pathways to shed light on the catalytic mechanisms. In this review, we summarize the latest progress in the rational design and engineering of SAzymes and their applications in biomedicine and biosensing. We then conclude the review with highlights of the remaining challenges and perspectives of this emerging technology.

Graphical abstract: Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

Article information

Article type
Chemistry Frontiers
Submitted
08 Mar 2023
Accepted
19 Apr 2023
First published
20 Apr 2023

Inorg. Chem. Front., 2023,10, 4289-4312

Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

X. Xiao, X. Hu, Q. Liu, Y. Zhang, G. Zhang and S. Chen, Inorg. Chem. Front., 2023, 10, 4289 DOI: 10.1039/D3QI00430A

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