Photo and acid dual degradable polymeric nanoparticles from an o-nitrobenzyl dithiol with thiol–ene click polymerization

Ming Zhang; Daai Li; Pengfei Shan; Xiaoyue Lian; Yuxi Qi; Kaicheng Du; Guoquan Ma; Liang Cai; Zhihui Li; Zhongyu Li

doi:10.1039/D3PY00586K

Photo and acid dual degradable polymeric nanoparticles from an o-nitrobenzyl dithiol with thiol–ene click polymerization†

Ming Zhang,‡^a Daai Li,‡^a Pengfei Shan,^ab Xiaoyue Lian,^b Yuxi Qi,^a Kaicheng Du,^a Guoquan Ma,^a Liang Cai,^a Zhihui Li*^b and Zhongyu Li

*^a

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* Corresponding authors

^a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China
E-mail: lizy@wzu.edu.cn

^b School of Optometry and Ophthalmology and Eye Hospital, State Key Laboratory of Optometry & Vision Science, Wenzhou Medical University, Wenzhou 325027, China
E-mail: smart_dream@wmu.edu.cn

Abstract

Herein, a dithiol reagent containing o-nitrobenzyl structure was designed, and the polymer PKNB with alternating ketal and o-nitrobenzyl structures and the amphiphilic triblock copolymer mPEG-PKNB-mPEG were obtained from this reagent through thiol–ene click chemistry. Our results showed that mPEG-PKNB-mPEG and its nanoparticles showed excellent light/acid degradation ability, which will have great potential in the fields of drug, gene, or pesticide delivery.

Polymer Chemistry

Photo and acid dual degradable polymeric nanoparticles from an o-nitrobenzyl dithiol with thiol–ene click polymerization†

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Photo and acid dual degradable polymeric nanoparticles from an o-nitrobenzyl dithiol with thiol–ene click polymerization

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