Issue 38, 2023

Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents

Abstract

Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic β-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance.

Graphical abstract: Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents

Supplementary files

Article information

Article type
Communication
Submitted
07 Aug 2023
Accepted
31 Aug 2023
First published
31 Aug 2023
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2023,21, 7702-7706

Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents

A. M. Caramiello, M. C. Bellucci, E. Ottaviano, S. Ancona, E. Borghi and A. Volonterio, Org. Biomol. Chem., 2023, 21, 7702 DOI: 10.1039/D3OB01247F

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