Deoxyestrone-based lipofection agents with solution- and solid-state emission properties

Alexander Huber; Johannes Koch; Kevin Rudolph; Alexander Höing; Fabio Rizzo; Shirley K. Knauer; Jens Voskuhl

doi:10.1039/D3OB00656E

Deoxyestrone-based lipofection agents with solution- and solid-state emission properties†

Alexander Huber,^a Johannes Koch,^b Kevin Rudolph,^a Alexander Höing,

^c Fabio Rizzo,

^de Shirley K. Knauer

^c and Jens Voskuhl

*^a

Author affiliations

* Corresponding authors

^a Faculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45117 Essen, Germany
E-mail: jens.voskuhl@uni-due.de

^b Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany

^c Department of Molecular Biology II, Center of Medical Biotechnology (ZMB), University of Duisburg Essen, Universitätsstraße 2, 45141 Essen, Germany

^d Center for Soft Nanoscience (SoN), Westfälische Wilhelms-Universität Münster, Busso-Peus-Straße 10, 48149 Münster, Germany

^e Institute of Chemical Science and Technologies “G. Natta” (SCITEC), National Research Council (CNR), Via G. Fantoli 16/15, 20138 Milan, Italy

Abstract

In this contribution, three deoxyestrone-based emissive lipofection agents are reported. Because of a centrally incorporated terephthalonitrile motif, these ligands can be classified as solution and solid-state emitters (SSSEs). With the attachment of tobramycin, these amphiphilic structures are able to form lipoplexes, mediating gene transfection of HeLa and HEK 293T cells.

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Article information

DOI: https://doi.org/10.1039/D3OB00656E
Article type: Communication
Submitted: 27 Apr 2023
Accepted: 23 Jun 2023
First published: 23 Jun 2023
This article is Open Access

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Org. Biomol. Chem., 2023,21, 5762-5767

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Deoxyestrone-based lipofection agents with solution- and solid-state emission properties

A. Huber, J. Koch, K. Rudolph, A. Höing, F. Rizzo, S. K. Knauer and J. Voskuhl, Org. Biomol. Chem., 2023, 21, 5762 DOI: 10.1039/D3OB00656E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Organic & Biomolecular Chemistry

Deoxyestrone-based lipofection agents with solution- and solid-state emission properties†

Abstract

Supplementary files

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Deoxyestrone-based lipofection agents with solution- and solid-state emission properties

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