Yunzhou Li, Shaomin Fu and Bo Liu
Org. Biomol. Chem., 2023,21, 4409-4413
DOI:
10.1039/D3OB00575E,
Communication
Aromatic ent-pimaranes are a group of aromatized tricyclic diterpenoids that exhibit diverse bioactivities. In this work, the first total syntheses of two aromatic ent-pimaranes were achieved via a C-ABC construction sequence enabled by chiral auxiliary controlled asymmetric radical polyene cyclization, and the subsequent substrate-controlled stereo-/regio-specific hydroboration of alkene allowed for access to both natural products with C19 oxidation modifications.