Wei Wang, Zhaoliang Qin, Xinhui Zhang, Wanxiang Zhao and Wen Yang
Org. Biomol. Chem., 2023,21, 4304-4308
DOI:
10.1039/D3OB00566F,
Paper
An efficient catalyst-free C(sp3)–H bond functionalization of methyl azaarenes with heteroaromatic trifluoromethyl ketone hydrates in neat water has been developed for the synthesis of α-trifluoromethyl tertiary alcohols bearing N-heteroaromatics. This method not only features excellent efficiency, broad substrate scope, catalyst-free conditions, and easy gram-scale preparation but also represents a new and rare example of “all-water” synthesis of trifluoromethylated molecules.