Issue 22, 2023

Recent advances in the accessibility, synthetic utility, and biological applications of aziridines

Abstract

Compounds featuring aziridine moieties are widely known and extensively reported in the literature. Due to their great potential from both synthetic and pharmacological points of view, many researchers have focused their efforts on the development of new methodologies for the preparation and transformation of these interesting compounds. Over the years, more and more ways to obtain molecules bearing these three-membered functional groups, which are challenging due to their inherent reactivity, have been described. Among them, several are more sustainable. In this review, we report the recent advances in the biological and chemical evolution of aziridine derivatives, in particular, the variety of methodologies described for the synthesis of aziridines and their chemical transformations leading to the formation of interesting derivatives, such as 4–7 membered heterocycles of pharmaceutical interest due to their promising biological activities.

Graphical abstract: Recent advances in the accessibility, synthetic utility, and biological applications of aziridines

Article information

Article type
Review Article
Submitted
18 Mar 2023
Accepted
12 May 2023
First published
15 May 2023
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2023,21, 4553-4573

Recent advances in the accessibility, synthetic utility, and biological applications of aziridines

C. Dank and L. Ielo, Org. Biomol. Chem., 2023, 21, 4553 DOI: 10.1039/D3OB00424D

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