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Reported here is the synthesis of a naphthalene-based macrocycle bearing anionic carboxylato groups on the rims along with its complexation with cationic guests in aqueous media. The macrocycle could strongly bind guests in a molecular clip model with association constants of 106–107 M−1.

Graphical abstract: Synthesis of a water-soluble naphthalene-based macrocycle and its host–guest properties

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