Issue 17, 2023

Formal synthesis of cyclotheonellazole A

Abstract

A convergent procedure for the formal synthesis of cyclotheonellazole A in high yields and excellent stereoselectivity has been developed. This synthesis features an efficient preparation of O-pivaloyl-protected α-hydroxy-β-amino amides and a one-pot process to introduce the challenging thiazole moiety. The overall synthesis is very efficient and paves the way for the preparation of analogues for drug development.

Graphical abstract: Formal synthesis of cyclotheonellazole A

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
07 Jan 2023
Accepted
27 Mar 2023
First published
29 Mar 2023

Org. Biomol. Chem., 2023,21, 3531-3536

Formal synthesis of cyclotheonellazole A

B. Long, L. Pu, Z. Liu, X. Zeng and Z. Wu, Org. Biomol. Chem., 2023, 21, 3531 DOI: 10.1039/D3OB00038A

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