Enhanced chemodynamic and photoluminescence efficiencies of Fe–O4 coordinated carbon dots via the core–shell synergistic effect

Abstract

In natural systems like photosynthetic organisms and photo-active enzymes, the spatial organization of chromophores is critical for efficient light harvesting and bio-catalysis. Inspired by nature, a novel modular nanoplatform with both biological imaging and therapeutic functions is constructed by taking advantage of the intrinsic core–shell structure of Fe-decorated carbon dots. Light-harvesting chromophores with deep-red photoluminescence are densely packed into the carbon core. Simultaneously, the atomically dispersed Fe³⁺ catalytic sites accounting for efficient conversion of H₂O₂ to ˙OH are discretely distributed on the shell. Precise control over their spatial distribution leads to the elegant integration and exciting interplay of the functional moieties. On the one hand, incorporating a catalysis shell enhances the emission of chromophores via synergistic shielding and rigidifying effects. On the other hand, visible light excitation of the chromophores significantly increases the catalytic activity and cytotoxicity against cancer cells, ascribed to the promotion of the charge transfer process. This nanoplatform exhibits excellent biocompatibility, bright red fluorescence, and light-regulated cytotoxicity for anti-cancer treatment, promising its applications in smart nanocatalytic medicines and efficient chemodynamic therapy.