Revisiting the manzamine biosynthetic hypothesis

Abstract

Covering: up to 2023

The marine environment represents a rich yet challenging source of novel therapeutics. These challenges are best exemplified by the manzamine class of alkaloids, featuring potent bioactivities, difficult procurement, and a biosynthetic pathway that has eluded characterization for over three decades. This review highlights postulated biogenic pathways toward the manzamines, evaluated in terms of current biosynthetic knowledge and metabolic precedent.

Graphical abstract: Revisiting the manzamine biosynthetic hypothesis

Article information

Article type
Highlight
Submitted
22 Nov 2022
First published
17 Jan 2023

Nat. Prod. Rep., 2023, Advance Article

Revisiting the manzamine biosynthetic hypothesis

A. T. Piwko, B. G. Miller and J. M. Smith, Nat. Prod. Rep., 2023, Advance Article , DOI: 10.1039/D2NP00082B

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