Issue 24, 2023

β-Galactosidase-instructed intracellular nanofiber formation enhances tumor micro-PET imaging

Abstract

Enzyme-instructed self-assembly is a key approach to prepare well-controlled nanostructures for clinical development. Herein, we report a novel probe, [68Ga]Nap-1G which self-assembles into nanofibers under the hydrolysis of β-galactosidase. We demonstrate that its high accumulation enhances micro-PET imaging of tumors.

Graphical abstract: β-Galactosidase-instructed intracellular nanofiber formation enhances tumor micro-PET imaging

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2023
Accepted
23 May 2023
First published
24 May 2023

New J. Chem., 2023,47, 11376-11379

β-Galactosidase-instructed intracellular nanofiber formation enhances tumor micro-PET imaging

M. Wang, K. Yu, D. Zhu, P. Zou, P. Chen, H. Wang, Y. Liu and M. Xie, New J. Chem., 2023, 47, 11376 DOI: 10.1039/D3NJ01967E

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