Azulene tethered N-aryl nucleobases: synthesis, morphology and biochemical evaluations

Abstract

Azulene is a non-benzenoid aromatic molecule comprising unique structural and functional properties. Herein, we report four new azulene-based N-aryl nucleobases via nucleophilic aromatic substitution (S_NAr) exhibiting distinct morphologies with no cytotoxic effect toward the HEK293T cell line. The silver complex of the cytosine derivative, i.e. the silver nanocomposite (Ag–C-complex), has also been synthesized, showing antibacterial properties against Pseudomonas aeruginosa (PA14) with a minimum inhibitory concentration of 20 µM.