Phenylboronic acid conjugated poly(3,4-ethylenedioxythiophene) (PEDOT) coated Ag dendrite for electrochemical non-enzymatic glucose sensing

Abstract

Blood glucose monitoring is the premise and basis of diabetes diagnosis and treatment. Previously, we developed polythiophene modified by phenylboronic acid derivatives for non-enzyme detection of glucose and discussed the effect of the structure of phenylboronic acid on the response to glucose. In this study, we investigated the effect of the surface morphology of phenylboronic acid-modified polythiophene (poly(EDOT-PBA)) on glucose-sensing performance. To this end, we developed a fern leaf-like structured poly(EDOT-PBA) film and discussed the effect of surface morphology of poly(EDOT-PBA) for glucose sensing. The modified electrode surfaces were characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, static water contact angle, and impedance measurements. The specific interaction between PBA and glucose was detected by impedancemetry. The concentration-dependent specific response was observed in glucose solution. The sensitivity was 426.1 Ω mM⁻¹ cm⁻² in 0.05–30 mM with a limit of detection of 0.01 mM. The glucose sensor has good selectivity and stability.