Issue 6, 2023

The influence of surface ligand chemistry for the synthesis of blue fluorescent gold nanoclusters for the detection of serotonin in biofluids

Abstract

Gold nanoclusters have been widely applied for the sensing of biomolecules, biomarkers and drugs. Herein, a simple method for the fabrication of gold nanoclusters (Au NCs) is put forward by using two ligands, namely 6-thioguanine (6-TG) and tryptophan (Trp). First, blue emitting 6-TG-Au NCs have been synthesized and then the surface of the 6-TG-Au NCs was modified with Trp. This surface modification results in the enhancement of the fluorescence intensity with a red shift in the emission peak confirming the formation of 6-TG-Trp-Au NCs. The as-synthesized 6-TG-Trp-Au NCs work as a fluorescent sensor for the sensitive recognition of biomarker serotonin. The 6-TG-Trp-Au NCs exhibit a strong emission peak at 473 nm when excited at 380 nm. The 6-TG-Trp-Au NC-based method shows a fluorescence turn-off mechanism toward serotonin with a linear range of 0.041–1.25 μM and limit of detection of 5.58 nM. Moreover, 6-TG-Trp-Au NCs show a quick response for the development of a cost-effective analytical strategy for a serotonin assay in biofluids.

Graphical abstract: The influence of surface ligand chemistry for the synthesis of blue fluorescent gold nanoclusters for the detection of serotonin in biofluids

Supplementary files

Article information

Article type
Paper
Submitted
28 Sep 2022
Accepted
30 Dec 2022
First published
03 Jan 2023

New J. Chem., 2023,47, 3075-3083

The influence of surface ligand chemistry for the synthesis of blue fluorescent gold nanoclusters for the detection of serotonin in biofluids

S. Borse, Z. V. P. Murthy, T. J. Park and S. K. Kailasa, New J. Chem., 2023, 47, 3075 DOI: 10.1039/D2NJ04797G

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