Issue 24, 2023

Nanoparticle-based applications by atmospheric pressure matrix assisted desorption/ionization mass spectrometry

Abstract

Recently, the development of atmospheric pressure matrix assisted desorption/ionization mass spectrometry (AP MALDI MS) has made contributions not only to biomolecule analysis but also to spatial distribution. This has positioned AP MALDI as a powerful tool in multiple domains, thanks to its comprehensive advantages compared to conventional MALDI MS. These developments have addressed challenges associated with previous AP MALDI analysis systems, such as optimization of apparatus settings, synthesis of novel matrices, preconcentration and isolation strategies before analysis. Herein, applications in different fields using AP MALDI MS were described, including peptide and protein analysis, metabolite analysis, pharmaceutical analysis, and mass spectrometry imaging.

Graphical abstract: Nanoparticle-based applications by atmospheric pressure matrix assisted desorption/ionization mass spectrometry

Article information

Article type
Minireview
Submitted
04 Sep 2023
Accepted
20 Oct 2023
First published
30 Oct 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 6804-6818

Nanoparticle-based applications by atmospheric pressure matrix assisted desorption/ionization mass spectrometry

Y. Wang, S. Li and K. Qian, Nanoscale Adv., 2023, 5, 6804 DOI: 10.1039/D3NA00734K

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