Microwave-assisted, ionic liquid-catalyzed aminolysis and alcoholysis of phosphinic derivatives: the interconversion of phosphinates and phosphinic amides

Abstract

A chlorine-free and simple method was developed for the preparation of alkylamino-3-phospholene oxides and for the diastereoselective synthesis of alkylaminophospholane oxides by the MW-assisted ionic liquid-catalyzed aminolysis of the corresponding cyclic phosphinates. The opposite reaction, the alcoholysis of cyclic phosphinic amides, was also elaborated. The interconversion of phosphinates and phosphinic amides may be of more general value.