Solvent-free and catalyst-free direct alkylation of alkenes

Meng-Yao Li; Jiatong Li; Ao Gu; Xiao-Mei Nong; Shuyang Zhai; Zhu-Ying Yue; Chen-Guo Feng; Yingbin Liu; Guo-Qiang Lin

doi:10.1039/D3GC02685J

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Solvent-free and catalyst-free direct alkylation of alkenes†‡

Meng-Yao Li,

§^a Jiatong Li,§^a Ao Gu,^a Xiao-Mei Nong,^a Shuyang Zhai,^a Zhu-Ying Yue,^a Chen-Guo Feng,

*^b Yingbin Liu*^a and Guo-Qiang Lin^b

Author affiliations

* Corresponding authors

^a State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
E-mail: laoniulyb@shsmu.edu.cn

^b The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
E-mail: fengcg@shutcm.edu.cn

Abstract

A convenient method for synthesizing aryl-containing trisubstituted alkenes through direct alkylation of alkenes was successfully achieved under solvent-free and catalyst-free conditions. The absence of solvents was found to be crucial in initiating this sequence. Moreover, this protocol stands out due to its minimal waste production and straightforward operation. The radical capture experiment provided evidence for an ionic reaction mechanism.

This article is part of the themed collection: 130th Anniversary of Wuhan University

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Article information

DOI: https://doi.org/10.1039/D3GC02685J
Article type: Communication
Submitted: 22 Jul 2023
Accepted: 11 Aug 2023
First published: 15 Aug 2023

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Green Chem., 2023,25, 7073-7078

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Solvent-free and catalyst-free direct alkylation of alkenes

M. Li, J. Li, A. Gu, X. Nong, S. Zhai, Z. Yue, C. Feng, Y. Liu and G. Lin, Green Chem., 2023, 25, 7073 DOI: 10.1039/D3GC02685J

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Green Chemistry

Solvent-free and catalyst-free direct alkylation of alkenes†‡

Abstract

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Solvent-free and catalyst-free direct alkylation of alkenes

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