An efficient and eco-compatible multicomponent synthesis of 2,4,5-trisubstituted imidazole derivatives using modified-silica-coated cobalt ferrite nanoparticles with tungstic acid

Abstract

The aim of this study has been to offer a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on green chemistry principles. Therefore, a one-pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate and 1,2-diketone under solvent-free conditions was utilized as an eco-effective synthetic route using CoFe₂O₄@SiO₂@(–CH₂)₃OWO₃H NPs as the catalyst. The stabilized tungstic acid on 3-chloropropyl-anchored SiO₂-coated CoFe₂O₄ magnetic nanoparticles was designed, prepared, and applied as a recyclable heterogeneous acid catalyst to attain high product yield in a short reaction time. The nanocatalyst structure was confirmed using FT-IR, Raman, XRD, FE-SEM, EDX, VSM, and TGA techniques, and the organic product structures were examined by melting point, FT-IR and ¹H NMR analyses.