Issue 46, 2023

Chiral selectivity vs. noise in spontaneous mirror symmetry breaking


Mirror symmetry breaking bifurcations, that occur in nonlinear chemical systems leading to final chiral states with very large enantiomeric excess, can be exploited as an efficient chiral signal selector for even the smallest chiral polarizations. This effect of the chiral polarization requires the system's capacity for overcoming thermal noise, which is manifested as fluctuating reaction rate constants. Therefore, we investigate the chiral selectivity across a range of tiny parity-violating energy differences (PVED) in the presence of inevitable non-equilibrium temperature fluctuations. We use a stochastic differential equation simulation methodology (Ito process) that serves as a valuable tool in open systems for identifying the thresholds at which the chiral force induces chiral selectivity in the presence of non-equilibrium temperature fluctuations. This approach enables us to include and analyze chiral selectivity in the presence of other types of fluctuations, such as perturbations in the rate of fluid flow into and out of the reactor and in the clamped input concentrations. These concepts may be of practical interest (i.e., spontaneous deracemizations) but are also useful for a better understanding of the general principles governing the emergence of biological homochirality.

Graphical abstract: Chiral selectivity vs. noise in spontaneous mirror symmetry breaking

Article information

Article type
13 Jul 2023
10 Oct 2023
First published
12 Oct 2023
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2023,25, 31583-31595

Chiral selectivity vs. noise in spontaneous mirror symmetry breaking

D. Hochberg, T. Buhse, J. Micheau and J. M. Ribó, Phys. Chem. Chem. Phys., 2023, 25, 31583 DOI: 10.1039/D3CP03311B

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