Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

Toshiyuki Sasaki; Takanori Nakane; Akihiro Kawamoto; Tomohiro Nishizawa; Genji Kurisu

doi:10.1039/D2CE01522F

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization†

Toshiyuki Sasaki,

‡*^a Takanori Nakane,

‡^b Akihiro Kawamoto,

^b Tomohiro Nishizawa

^c and Genji Kurisu

*^bde

Author affiliations

* Corresponding authors

^a Department of Materials System Science, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa 236-0027, Japan
E-mail: tsasaki@yokohama-cu.ac.jp, t.devi.sasaki@gmail.com

^b Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
E-mail: gkurisu@protein.osaka-u.ac.jp

^c Department of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

^d Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka 560-0043, Japan

^e Institute for Open and Transdisciplinary Research Initiatives, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

Abstract

Solid-state grinding can provide “mechano-distinctive” co-crystals that are not accessible from solutions. Herein, we demonstrate the structure determination of a powdered mechano-distinctive co-crystal of 2-aminopyrimidine and succinic acid in a 2 : 1 molar ratio using microcrystal electron diffraction.

$Graphical abstract: Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization$

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Article information

DOI: https://doi.org/10.1039/D2CE01522F
Article type: Communication
Submitted: 10 Nov 2022
Accepted: 23 Dec 2022
First published: 24 Dec 2022
This article is Open Access

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CrystEngComm, 2023,25, 352-356

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Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

T. Sasaki, T. Nakane, A. Kawamoto, T. Nishizawa and G. Kurisu, CrystEngComm, 2023, 25, 352 DOI: 10.1039/D2CE01522F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

CrystEngComm

Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization†

Abstract

Supplementary files

Article information

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Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization

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