Issue 83, 2023

Ketosulfonylmethylenation and sulfonylethyleneation of imidazoheterocycles with dimethylformamide as a methylene source

Abstract

A hitherto unreported ketosulfonylmethylenation occurring at the C-3 position of imidazoheterocycles, with dimethylformamide as the methylene source was described. Using CoCl2ยท6H2O or Fe(acac)3 as efficient and inexpensive catalysts, some important biologically active methylenated compounds were prepared, with high efficacy, favorable functional group compatibilities, and a broad substrate scope.

Graphical abstract: Ketosulfonylmethylenation and sulfonylethyleneation of imidazoheterocycles with dimethylformamide as a methylene source

Supplementary files

Article information

Article type
Communication
Submitted
09 Aug 2023
Accepted
21 Sep 2023
First published
26 Sep 2023

Chem. Commun., 2023,59, 12455-12458

Ketosulfonylmethylenation and sulfonylethyleneation of imidazoheterocycles with dimethylformamide as a methylene source

T. Guo, P. Hu, Y. Liu, P. Zhang, Y. Zhao and C. Zhu, Chem. Commun., 2023, 59, 12455 DOI: 10.1039/D3CC03850E

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