Issue 91, 2023

Water-soluble endohedral metallofullerenes: new horizons for biomedical applications

Abstract

Endohedral metallofullerenes (EMFs) offer a safe avenue to manipulate metals important to biomedical applications such as MRI contrast, X-ray contrast, radiolabeling, radiotherapy, chemotherapy, and the control of inflammation by scavenging reactive oxygen species (ROS). Moreover, functionalizing the double bonds on the surface of EMFs modifies their solubility, supramolecular behaviour, binding, targeting characteristics, and physical properties. While most existing water-soluble derivatives possess a statistical mixture of appended functional groups, progress has been made in creating molecularly-precise derivatives with a defined number of surface functional groups, leading to potentially more nuanced control of their behaviour and properties. Further elucidation of the structure–function relationships of these materials is expected to enhance their utility in biomedical applications and possibly broaden their use in diverse areas of science and technology.

Graphical abstract: Water-soluble endohedral metallofullerenes: new horizons for biomedical applications

Article information

Article type
Feature Article
Submitted
26 Jul 2023
Accepted
05 Oct 2023
First published
12 Oct 2023

Chem. Commun., 2023,59, 13551-13561

Author version available

Water-soluble endohedral metallofullerenes: new horizons for biomedical applications

W. P. Kopcha, R. Biswas, Y. Sun, S. D. Chueng, H. C. Dorn and J. Zhang, Chem. Commun., 2023, 59, 13551 DOI: 10.1039/D3CC03603K

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