ATP-responsive Mn(II)-based T1 contrast agent for MRI

Sellamuthu Anbu; Lawerence Kenning; Graeme J. Stasiuk

doi:10.1039/D3CC03430E

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ATP-responsive Mn(ii)-based T₁ contrast agent for MRI†

Sellamuthu Anbu,

*^ab Lawerence Kenning^c and Graeme J. Stasiuk

*^d

Author affiliations

* Corresponding authors

^a Departments of Chemistry and Biomedical Sciences, University of Hull, Cottingham Road, Hull, UK
E-mail: bioinorg_anbu@yahoo.com

^b School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, UK

^c MRI Centre, Royal Infirmary Hospital NHS Trust, Anlaby Road, Hull, UK

^d Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas’ Hospital, London, UK
E-mail: graeme.stasiuk@kcl.ac.uk

Abstract

A novel diacetylpyridylcarbohydrazide–DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn²⁺) arms (MnL^DPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T₁ contrast applications. Compound 2 shows enhanced relaxivity (r₁ = 11.52 mM⁻¹ s⁻¹) upon selective ATP binding over other phosphates.

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Article information

DOI: https://doi.org/10.1039/D3CC03430E
Article type: Communication
Submitted: 17 Jul 2023
Accepted: 19 Sep 2023
First published: 19 Sep 2023
This article is Open Access

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Chem. Commun., 2023,59, 13623-13626

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ATP-responsive Mn(II)-based T₁ contrast agent for MRI

S. Anbu, L. Kenning and G. J. Stasiuk, Chem. Commun., 2023, 59, 13623 DOI: 10.1039/D3CC03430E

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Chemical Communications