Issue 84, 2023

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Abstract

We report the development of the first metallo-PROTAC, specifically a Pt-PROTAC, that can effectively degrade select Pt(II)-binding proteins. The Pt-PROTAC prototype successfully degraded thioredoxin-1 and thioredoxin reductase-1 in multiple myeloma cancer cell lines. Metallo-PROTACs will have important applications in the identification of metal binding proteins and as chemotherapeutic agents.

Graphical abstract: First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

Supplementary files

Article information

Article type
Communication
Submitted
11 Jul 2023
Accepted
28 Sep 2023
First published
28 Sep 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 12641-12644

First-in-class metallo-PROTAC as an effective degrader of select Pt-binding proteins

P. D. O’Dowd, G. P. Sullivan, D. A. Rodrigues, T. N. Chonghaile and D. M. Griffith, Chem. Commun., 2023, 59, 12641 DOI: 10.1039/D3CC03340F

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