Issue 59, 2023

Group 13 ion coordination to pyridyl models NAD+ reduction potentials

Abstract

N-alkylation and N-metallation of pyridine are explored herein to understand how metal-ligand complexes can model NAD+ redox chemistry. Syntheses of substituted dipyrazolylpyridine (pz2P) compounds (pz2P)Me+ (1+) and (pz2P)GaCl2+ (2+) are reported, and compared with (pz2P)AlCl2(THF)+ and transition element pz2P complexes from previous reports. Cyclic voltammetry measurements of cationic 1+ and 2+ show irreversible reduction events ∼900 mV anodic those for neutral pz2P complexes of divalent metals. We proposed that N-metallation using Group 13 ions of 3+ charge provides an electrochemical model for N-alkylated pyridyls like NAD+.

Graphical abstract: Group 13 ion coordination to pyridyl models NAD+ reduction potentials

Supplementary files

Article information

Article type
Communication
Submitted
27 May 2023
Accepted
25 Jun 2023
First published
26 Jun 2023

Chem. Commun., 2023,59, 9110-9113

Author version available

Group 13 ion coordination to pyridyl models NAD+ reduction potentials

L. W. T. Parsons, J. C. Fettinger and L. A. Berben, Chem. Commun., 2023, 59, 9110 DOI: 10.1039/D3CC02562D

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