Issue 64, 2023

Nickel-catalyzed direct methylation of arylphosphines via carbon–phosphorus bond cleavage using AlMe3

Abstract

We report herein on the nickel-catalyzed methylation of arylphosphines using AlMe3via the cleavage of unactivated C(aryl)–P bonds. This reaction allows for the direct, catalytic substitution of an aryl group on a phosphorus center with a methyl group. This catalytic methylation can proceed, when phosphine oxides and sulfides are used as a substrate.

Graphical abstract: Nickel-catalyzed direct methylation of arylphosphines via carbon–phosphorus bond cleavage using AlMe3

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2023
Accepted
11 Jul 2023
First published
12 Jul 2023

Chem. Commun., 2023,59, 9722-9725

Author version available

Nickel-catalyzed direct methylation of arylphosphines via carbon–phosphorus bond cleavage using AlMe3

T. Igarashi, R. Shimazumi, N. Chatani and M. Tobisu, Chem. Commun., 2023, 59, 9722 DOI: 10.1039/D3CC02455E

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