Lingheng Kong, Xi Han, Panjie Hu, Fen Wang and Xingwei Li
Chem. Commun., 2023,59, 6690-6693
DOI:
10.1039/D3CC01666H,
Communication
Rhodium-catalyzed regio- and stereoselective three-component carboamidation of 1,3-enynes has been realized using indoles and dioxazolones as the functionalizing reagents. A wide range of multi-substituted skipped 1,4-dienes have been constructed in good yields and excellent stereoselectivity. The stereoselectivity is under substrate control. 1,3-Enynes bearing a relatively bulky alkyne terminus reacted with Z-selectivity. In contrast, a sterically less hindered alkyne terminus tends to predominantly give the E-configured skipped diene.