Issue 40, 2023
From the journal:

Chemical Communications

Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity†

Yusuke Sato, ORCID logo *a   Yoshihide Takaku,a   Toshiaki Nakano, ORCID logo b   Ken Akamatsu,*b   Dai Inamuraa  and  Seiichi Nishizawa ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
E-mail: yusuke.sato.a7@tohoku.ac.jp, seiichi.nishizawa.c8@tohoku.ac.jp

b DNA damage chemistry research group, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Kizugawa, Japan
E-mail: akamatsu.ken@qst.go.jp

Abstract

Dimethyllumazine (DML)-thiazole orange (TO) conjugates were developed for fluorescence sensing of thymine glycol (Tg)-containing DNAs based on the selective recognition of the A nucleobase opposite the Tg residue. Additionally, this conjugate has demonstrated an inhibitory activity towards endonuclease III, a DNA repair enzyme, through its competitive binding to Tg-containing DNAs.

Graphical abstract: Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC01501G
Article type
Communication
Submitted
28 Mar 2023
Accepted
25 Apr 2023
First published
25 Apr 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 6088-6091

Permissions

Request permissions

Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity

Y. Sato, Y. Takaku, T. Nakano, K. Akamatsu, D. Inamura and S. Nishizawa, Chem. Commun., 2023, 59, 6088 DOI: 10.1039/D3CC01501G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements