Issue 44, 2023
From the journal:

Chemical Communications

Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress†

Mieko Tsuji, ORCID logo *a   Haruno Taira,a   Taro Udagawa, ORCID logo b   Tatsuya Aoki,a   Tasuku Hirayama ORCID logo a  and  Hideko Nagasawa ORCID logo *a  

* Corresponding authors

a Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, Japan
E-mail: tsuji@gifu-pu.ac.jp, hnagasawa@gifu-pu.ac.jp

b Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

Abstract

We developed a caged hydroperoxide, BhcTBHP, releasing prooxidant TBHP under blue light irradiation. MitoTBHP with triphenylphosphonium at position 7 triggered selective oxidative stress and membrane depolarization in mitochondria upon photoirradiation. This study presents a powerful tool for studying redox signaling and oxidative stress in living cells.

Graphical abstract: Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

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Article information

DOI
https://doi.org/10.1039/D3CC01192E
Article type
Communication
Submitted
10 Mar 2023
Accepted
07 May 2023
First published
12 May 2023

Chem. Commun., 2023,59, 6706-6709

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Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

M. Tsuji, H. Taira, T. Udagawa, T. Aoki, T. Hirayama and H. Nagasawa, Chem. Commun., 2023, 59, 6706 DOI: 10.1039/D3CC01192E

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