Issue 33, 2023
From the journal:

Chemical Communications

The synergistic effect of Cu-MOF nanoparticles and immunomodulatory agent on SARS-CoV-2 inhibition†

Aleksander Ejsmont, ORCID logo a   Alicja Warowicka,bc   Justyna Broniarczykb  and  Joanna Goscianska ORCID logo *a  

* Corresponding authors

a Adam Mickiewicz University, Faculty of Chemistry, Department of Chemical Technology, Uniwersytetu Poznańskiego 8, Poznań 61-614, Poland
E-mail: asiagosc@amu.edu.pl

b Adam Mickiewicz University, Faculty of Biology, Department of Molecular Virology, Institute of Experimental Biology, Uniwersytetu Poznańskiego 6, Poznań 61-614, Poland

c NanoBioMedical Centre, Wszechnicy Piastowskiej 3, Poznań 61-614, Poland

Abstract

In this work, HKUST-1 and Cu-BDC nanoparticles were used as delivery systems for the early anti-COVID-19 drug, hydroxychloroquine. The antiviral MOF/drug combinations significantly reduced the infectivity of SARS-CoV-2, which can be attributed to the nanometric size of the carriers, the presence of copper in the MOF nodes, and the semi-controlled release of the drug.

Graphical abstract: The synergistic effect of Cu-MOF nanoparticles and immunomodulatory agent on SARS-CoV-2 inhibition

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Article information

DOI
https://doi.org/10.1039/D3CC00894K
Article type
Communication
Submitted
24 Feb 2023
Accepted
27 Mar 2023
First published
27 Mar 2023

Chem. Commun., 2023,59, 4907-4910

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The synergistic effect of Cu-MOF nanoparticles and immunomodulatory agent on SARS-CoV-2 inhibition

A. Ejsmont, A. Warowicka, J. Broniarczyk and J. Goscianska, Chem. Commun., 2023, 59, 4907 DOI: 10.1039/D3CC00894K

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