Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy

Mengzhen Wang; Kaixian Wang; Xiaohan Liu; Mingwan Shi; Huiwen Zhang; Xia Zhang; Ruyue Wei; Na Li; Wei Pan; Bo Tang

doi:10.1039/D3CC00487B

Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy†

Mengzhen Wang,‡^a Kaixian Wang,‡^a Xiaohan Liu,^a Mingwan Shi,^a Huiwen Zhang,^a Xia Zhang,^a Ruyue Wei,^a Na Li,

^a Wei Pan

*^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: panwei@sdnu.edu.cn, tangb@sdnu.edu.cn

Abstract

We designed and synthesized tumor-targeted nanoflowers to inhibit glutamine metabolism and amplify oxidative stress, which could synergistically suppress tumor growth.

Chemical Communications

Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy†

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Tumor-targeted nanoflowers regulate glutamine metabolism and amplify oxidative stress for synergistic therapy

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