Gate-voltage-modulated electrostatic interaction between the probe and the channel material of FET biosensors for detecting telomerase

Abstract

A gate-voltage-modulated strategy was proposed to improve the detection performance of telomerase. We comprehensively investigated the mechanism for the gate-voltage-modulated detection performance by modulating the electrostatic interaction between charges of a single-stranded DNA probe and electrons of the In₂O₃ channel. This gate-voltage-modulated interaction between the probe and the channel can potentially serve as a universal strategy for high-performance FET biosensors.