Creation of single molecular conjugates of metal–organic cages and DNA

Toshinobu Nakajo; Shinpei Kusaka; Haruka Hiraoka; Kohei Nomura; Noriaki Matsubara; Rintaro Baba; Yuki Yoshida; Kosuke Nakamoto; Masakazu Honma; Hiroaki Iguchi; Takayuki Uchihashi; Hiroshi Abe; Ryotaro Matsuda

doi:10.1039/D3CC00460K

Creation of single molecular conjugates of metal–organic cages and DNA†

Toshinobu Nakajo,

^a Shinpei Kusaka,

^a Haruka Hiraoka,

^b Kohei Nomura,^b Noriaki Matsubara,^b Rintaro Baba,^b Yuki Yoshida,^b Kosuke Nakamoto,^b Masakazu Honma,^c Hiroaki Iguchi,

^a Takayuki Uchihashi,

^de Hiroshi Abe

^be and Ryotaro Matsuda

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
E-mail: ryotaro.matsuda@chembio.nagoya-u.ac.jp

^b Department of Chemistry, School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

^c Modality Research Laboratories 1, Research Unit, R&D Division, Kyowa Kirin Co., Ltd., Asahi-machi, Machida-shi, Tokyo 194-8533, Japan

^d Department of Physics, School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

^e Institute for Glyco-core Research (iGCORE), Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

Abstract

Here we report the development of an equimolar conjugate of a metal–organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.

Chemical Communications

Creation of single molecular conjugates of metal–organic cages and DNA†

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Creation of single molecular conjugates of metal–organic cages and DNA

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