Issue 25, 2023
From the journal:

Chemical Communications

Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations†

Yan Mao,ab   Wenxi Chen,ab   Changchang Li,b   Lin Miao,b   Yanfei Lin,b   Fei Ling, ORCID logo *a   Zhangpei Chen ORCID logo *c  and  Jinzhong Yao ORCID logo *b  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
E-mail: lingfei@zjut.edu.cn

b College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China
E-mail: jzyao@zju.edu.cn

c Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, China
E-mail: chenzhangpei@mail.neu.edu.cn

Abstract

An efficient method for the construction of various 3,4,5-trisubstituted phenol derivatives has been achieved via the Rh(III)-catalyzed coupling of phosphonium cations with internal alkynes. This protocol shows good substrate compatibility, as an array of structurally and electronically diverse phosphonium compounds react efficiently with up to 87% yield.

Graphical abstract: Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations

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Article information

DOI
https://doi.org/10.1039/D3CC00017F
Article type
Communication
Submitted
02 Jan 2023
Accepted
05 Mar 2023
First published
06 Mar 2023

Chem. Commun., 2023,59, 3775-3778

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Synthesis of 3,4,5-trisubstituted phenols via Rh(III)-catalyzed alkenyl C–H activation assisted by phosphonium cations

Y. Mao, W. Chen, C. Li, L. Miao, Y. Lin, F. Ling, Z. Chen and J. Yao, Chem. Commun., 2023, 59, 3775 DOI: 10.1039/D3CC00017F

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