Axisymmetric bis-tridentate Ir(III) photoredox catalysts for anticancer phototherapy under hypoxia

Li Wei; Rajesh Kushwaha; Anyi Dao; Zhongxian Fan; Samya Banerjee; Huaiyi Huang

doi:10.1039/D2CC06721H

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Axisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxia†

Li Wei,^a Rajesh Kushwaha,

^b Anyi Dao,^a Zhongxian Fan,^ac Samya Banerjee

^b and Huaiyi Huang

*^a

Author affiliations

* Corresponding authors

^a School of pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, P. R. China
E-mail: huanghy87@mail.sysu.edu.cn

^b Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, UP-221005, India

^c Shenshan Medical Center, Memorial Hospital of Sun Yat-Sen University, China

Abstract

A novel axisymmetric bis-tridentate Ir(III) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.

This article is part of the themed collection: Photofunctional Materials and Transformations

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Article information

DOI: https://doi.org/10.1039/D2CC06721H
Article type: Communication
Submitted: 09 Dec 2022
Accepted: 14 Feb 2023
First published: 14 Feb 2023

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Chem. Commun., 2023,59, 3083-3086

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Axisymmetric bis-tridentate Ir(III) photoredox catalysts for anticancer phototherapy under hypoxia

L. Wei, R. Kushwaha, A. Dao, Z. Fan, S. Banerjee and H. Huang, Chem. Commun., 2023, 59, 3083 DOI: 10.1039/D2CC06721H

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Chemical Communications

Axisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxia†

Abstract

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Axisymmetric bis-tridentate Ir(III) photoredox catalysts for anticancer phototherapy under hypoxia

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