The utility of active proteases as biomarkers is often limited by overlapping substrate specificity. Here, this feature is leveraged to develop a quantitative pattern-recognition sensing system driven by the degradation patterns of peptide–peptoid hybrid substrates to classify proteases and estimate their concentration by multivariate data analysis.
M. J. Austin, H. C. Schunk, N. Ling and A. M. Rosales, Chem. Commun., 2023, 59, 1685 DOI: 10.1039/D2CC06587H
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