A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity

Dan Zhang; Sifan Wang; Fangxi Yang; Qingrong Qi; Yanfang Li; Wencai Huang

doi:10.1039/D2CC06221F

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A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity†

Dan Zhang,^a Sifan Wang,^a Fangxi Yang,^a Qingrong Qi,^b Yanfang Li

*^a and Wencai Huang

*^a

Author affiliations

* Corresponding authors

^a School of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China
E-mail: lyf471@vip.163.com, hwc@scu.edu.cn

^b West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China

Abstract

The responses of a reaction-based fluorescent probe BI-Py towards alkyl halide, epoxide, carbonate, sulfate, sulphonate and triflate were evaluated and the probe achieved selective detection of ethyl triflate in acetonitrile with a LOD of 1.08 μM. BI-Py exhibited great potential for detecting triflate as a genotoxic impurity in drug substances.

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Article information

DOI: https://doi.org/10.1039/D2CC06221F
Article type: Communication
Submitted: 17 Nov 2022
Accepted: 23 Jan 2023
First published: 24 Jan 2023

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Chem. Commun., 2023,59, 2130-2133

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A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity

D. Zhang, S. Wang, F. Yang, Q. Qi, Y. Li and W. Huang, Chem. Commun., 2023, 59, 2130 DOI: 10.1039/D2CC06221F

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Chemical Communications

A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity†

Abstract

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A fluorescent probe for alkylating agents and its quantification of triflate as a genotoxic impurity

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