Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury

Jian Zhang; Yingying Xie; Jushuai Ma; Kaiqiang Liu; Yunshu Ding; Yong Li; Xiaoyun Jiao; Xilei Xie; Xu Wang; Bo Tang

doi:10.1039/D2CC06140F

Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury†

Jian Zhang,‡^a Yingying Xie,‡^a Jushuai Ma,^a Kaiqiang Liu,^a Yunshu Ding,^a Yong Li,^a Xiaoyun Jiao,^a Xilei Xie,^a Xu Wang*^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, wangxu@sdnu.edu.cn

Abstract

Two fluorescent probes (QM-S and QM-Se) featuring AIE properties were developed. The increased intracellular hypobromous acid (HOBr) in cardiomyocytes during MIRI was revealed with these probes. It was also observed that MIRI might be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which could mediate oxidative stress.

Chemical Communications

Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury

Social activity

Search articles by author

Spotlight

Advertisements