Issue 7, 2023

Single-cell thermometry with a nanothermocouple probe

Abstract

Herein, a nanopipette-based thermocouple probe that possesses high temperature resolution, rapid response, good reversibility and stability was constructed and successfully applied for single-cell temperature sensing. Different intracellular temperatures were observed in diverse types of cells, which reveals differences in their metabolism levels. Temperature responses of cancer and normal cells against various exogenous drugs were also demonstrated. The spatially resolved temperature sensing of three-dimensional cell culture models unveils the existence of their inner temperature gradients. This work would facilitate drug screening and disease diagnosis.

Graphical abstract: Single-cell thermometry with a nanothermocouple probe

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2022
Accepted
16 Dec 2022
First published
20 Dec 2022

Chem. Commun., 2023,59, 876-879

Single-cell thermometry with a nanothermocouple probe

L. Huang, X. Ding, X. Pan, Z. Li, K. Wang and X. Xia, Chem. Commun., 2023, 59, 876 DOI: 10.1039/D2CC06110D

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